Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in virto assessments with structure-activity relationship Al-Karmalawy, Ahmed A.; Alnajjar, Radwan; Abo Elmaaty, Ayman; Binjubair, Faizah A.; Al-Rashood, ,Sara T.; Mansour, Basma S. r; Eldehna, Wagdy M.; Ahmed Mansou, Khaled

In-Silico Evaluation, Chemical Reactivity, and Covalent Docking Study of Various Quinazolines and Pyridopyrimidines as Inhibitors for the Epidermal Growth Factor Receptor Khelfaoui, Hadjer; Harkati, Dalal; Saleh, Basil A.; Hewittc, Natalie L.; El-Hiti, Gamal A.; alnajjar, Radwan

Impact of pharmaceutical care intervention on health-related quality of life in hemodialysis patients in Benghazi Hussein, Maryam; Alshami, Hiba; Amer, E; Eltarhoni, Ali; , SofianAlmadani Hemodialysis patients suffer from poor health-related quality of life which results in a higher risk of hospitalization and mortality. This study investigates the importance of pharmaceutical care and role of pharmacist for hemodialysis patients to optimize drug therapy, minimize drug related problems and thereby improving their health-related quality of life. The study was conducted to evaluate the impact of pharmaceutical care interventions on health-related quality of life of hemodialysis patients in Benghazi, Libya. Randomized control study was carried out after getting an ethical approval from the committee of the hospital. Health-related quality of life was assessed using SF-36 instrument for all the patients (n = 80). Among them, 40 patients were received the normal care along with brief medication review and counselled by pharmacists for two months. Then, health-related quality of life was assessed again for those 40 patients who received the pharmaceutical care. Data was analyzed using an appropriate methods. The results showed that the quality of life for hemodialysis patients was poor in both physical and emotional aspects. After implementation of appropriate pharmaceutical care to the patients, their quality of life improved significantly. Health-related quality of life is an important determinant of treatment effectiveness in dialysis patients.

nvestigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies Farouk, Faten; Abo Elmaaty, Ayman; Elkamhawy, Ahmed; Haytham O., Tawfik; Alnajjar, Radwan; S. Abourehab, Mohammed A.; Saleh, Mohamed A.; Eldehna, Wagdy M.; Al‐Karmalawy, Ahmed A. Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the binding interactions of 138 antibiotics against the human topoisomerase II-DNA complex. Followed by the MD simulations for 200 ns and MM-GBSA calculations. On the other hand, the antitumor activities of the most promising candidates were investigated against three cancer cell lines using doxorubicin (DOX) as a reference drug. Notably, spiramycin (SP) and clarithromycin (CL) showed promising anticancer potentials on the MCF-7 cell line. Moreover, azithromycin (AZ) and CL exhibited good anticancer potentials against the HCT-116 cell line. Finally, the TOP-2 enzyme inhibition assay was carried out to confirm the proposed rationale. Briefly, potent TOP-2 inhibitory potentials were recorded for erythromycin (ER) and roxithromycin (RO). Additionally, a SAR study opened eyes to promising anticancer pharmacophores encountered by these antibiotics.